Baroque is set in a post-apocalyptic world where an experiment led by a being called Archangel to understand the Absolute God caused devastating climate change, with surviving humans becoming physically twisted by manifestations of guilt. The protagonist is guided by Archangel through the Neuro Tower to find the Absolute God and fix the world. The game features first person dungeon-crawling through randomly-generated floors of the Neuro Tower, with deaths in the dungeon advancing the narrative.